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<B>Correlation between androgen deprivation therapy and cognitive function
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   Lead Investigator:    Sophie Sokolow
   Institution      :    UCLA School of Nursing
   E-Mail           :    ssokolow@sonnet.ucla.edu
   Proposal ID      :    157
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>Androgen deprivation therapy (ADT) is the primary treatment for recurrent and     advance prostate cancer. ADT has been associated with increased risk for          adverse cardiovascular and metabolic disorders.  Recently, there have been some                                                                                                                                                                 indications that cognitive function may also decline following initiation of      ADT. Identification of cognitive decline in prostate cancer patients becomes      important for monitoring and management of treatment effects. The goals of the    current studies are to use the NACC database to identify longitudinal changes     in cognitive function in subjects taking ADT versus comparable subjects not       receiving ADT.                                                                                                                                                      Specific Aim:                                                                     To compare longitudinal changes in cognitive function in men started on ADT       over time with a matched group of matched males never receiving ADT? </textarea>